A Transcriptional Signature for Active TB: Have We Found the Needle in the Haystack?
نویسندگان
چکیده
Adithya Cattamanchi and colleagues reflect on recent research by Michael Levin and coworkers into the use of whole blood mRNA expression signatures to detect tuberculosis. The authors highlight challenges faced in getting this promising technology into clinics in low-resource settings. Please see later in the article for the Editors' Summary.
منابع مشابه
The Transcriptional Signature of Active Tuberculosis Reflects Symptom Status in Extra-Pulmonary and Pulmonary Tuberculosis
BACKGROUND Mycobacterium tuberculosis infection is a leading cause of infectious death worldwide. Gene-expression microarray studies profiling the blood transcriptional response of tuberculosis (TB) patients have been undertaken in order to better understand the host immune response as well as to identify potential biomarkers of disease. To date most of these studies have focused on pulmonary T...
متن کاملRadiological Findings in Active Pulmonary TB
ABSTRACT Pulmonary Tuberculosis (TB), usually is a chronic disease that caused by Mycobacterium Tuberculosis. Identification of the cases of TB is the key to control of it and radiology still plays a major role in both active and passive TB diagnosis. To assess the radiological patterns of presentation of active postprimary pulmonary TB, in this review and retrospective analysis, we studied C...
متن کاملEvaluation of Active Case Finding (ACF) of Tuberculosis in Slums Population in North of Iran
Background At present of the limitation of the current case finding strategies and the global urgency to improve tuberculosis (TB) case finding, a renewed interest in active case finding (ACF) has risen. World Health Organization (WHO) calls for research on TB screening among low-income countries because of the limitation of the passive case finding strategies. We aimed to evaluated Active Case...
متن کاملالگوی فصلی بیماری سل در ایران
Awareness regarding incidence pattern of disease is an important issue for researchers. To explore seasonal pattern of TB in Iran we decided to do this study. This study have been done as an ecologic study .all notified TB cases during 1997 to 2001 have been included in this study .all data have been processed and analyzed by the Cosinor analysis method. We found 59756 registered TB cases ...
متن کاملBlood transcriptomic diagnosis of pulmonary and extrapulmonary tuberculosis
BACKGROUND. Novel rapid diagnostics for active tuberculosis (TB) are required to overcome the time delays and inadequate sensitivity of current microbiological tests that are critically dependent on sampling the site of disease. Multiparametric blood transcriptomic signatures of TB have been described as potential diagnostic tests. We sought to identify the best transcript candidates as host bi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 10 شماره
صفحات -
تاریخ انتشار 2013